Buffalo defeated Eastern Michigan 31-30 in overtime in Week 6, a back-and-forth contest that saw 25 lead changes and kept both teams competitive throughout. The Bulls scored first on a 75-yard touchdown pass from Ta'Quan Roberson to Victor Snow in the first quarter, but Eastern Michigan answered immediately with a 45-yard touchdown from Noah Kim to Nick Devereaux.

The defenses made key plays early, with Eastern Michigan recording a 6.07-EPA defensive stop in the first quarter. Roberson continued his efficient play, completing 272 passing yards and adding another touchdown pass to Snow in the third quarter for 19 yards. Eastern Michigan responded with a 38-yard touchdown pass from Kim to Dontae McMillan in the same quarter.

A critical fourth-quarter play came when Kim was sacked for a 20-yard loss and fumbled, with Eastern Michigan recovering. Despite the defensive battle and multiple momentum shifts, Buffalo ultimately prevailed in overtime, 31-30. The game exceeded the over-under of 53.5 points, and Eastern Michigan covered the 9.5-point spread as the away team.