Austin Peay cruised to a 34-14 victory over Middle Tennessee in Week 1, with quarterback Chris Parson leading an efficient offensive performance. The Governors jumped out to an early advantage, scoring 14 points in the first quarter behind Parson's passing. Parson connected with receivers Shemar Kirk and Jaden Robinson for touchdowns, establishing control early.

Middle Tennessee managed to narrow the gap with a second-quarter touchdown, pulling within 21-7 at halftime. The Blue Raiders added another score in the third quarter when Nicholas Vattiato found Nahzae Cox for a 14-yard touchdown pass, but Austin Peay's offense proved too potent to overcome.

The Governors outscored MTSU 10-0 in the fourth quarter to seal the comfortable win. Austin Peay's defense produced several disruptive plays throughout, highlighted by three impactful stops in the first quarter alone. The victory came as Austin Peay covered the spread and the final score fell under the 53.5 over-under, finishing at 48 combined points. Parson's passing attack led the way as Austin Peay established itself as the superior team from opening kickoff.