Iowa State defeated Iowa 16-13 in a low-scoring defensive battle in Week 2. The Cyclones built an early lead, scoring 6 points in the first quarter and 7 in the second to take a 13-3 halftime advantage. Iowa answered with 10 second-quarter points to keep pace, but Iowa State's defense tightened in the second half, allowing only 3 third-quarter points before Iowa managed a fourth-quarter field goal.

The game featured four lead changes and remained competitive throughout, with Iowa State's defense making critical plays in the second and fourth quarters. Mark Gronowski led Iowa's passing attack with 83 yards, while Terrell Washington Jr. rushed for 8 yards. For Iowa State, Dominic Overby led receivers with 9 receptions.

Iowa State's defense dominated the statistical battle, with the top two defensive plays coming from Iowa's defense against Iowa State's offense. The final score of 16-13 came in under the 43-point over-under line, while the game pushed the 3-point spread.